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Incapable of being reversed or turned about or back; incapable of being made to run backward. examples
Incapable of being reversed, recalled, repealed, or annulled. quotations examples
Manganism has been known about since the 19th century, when miners exposed to ores containing manganese […] began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death.
2014 April 21, “Subtle effects”, in The Economist, volume 411, number 8884
(thermodynamics) Incapable of being reversed to the original state without consumption of free energy and increase of entropy. examples