Definition of "noxious"

In the living state, the body is observed to […] reject what is noxious; [...]

1822, John Barclay, chapter I, in An Inquiry Into the Opinions, Ancient and Modern, Concerning Life and Organization‎, Edinburgh, London: Bell & Bradfute; Waugh & Innes; G. & W. B. Whittaker, section I, page 1

[...] many old sewers have been neglected and are in dire need of repair. If that repair does not come in time, the result is noxious and potentially hazardous.

2014 June 14, “It's a gas”, in The Economist, volume 411, number 8891