Definition of "exulceration"

[…] and thus it is likewiſe of ſervice in choletic Conſtitutions, and where the Shapneſs of Humours threatens Excoriations and Exulcerations.

1719, John Quincy, Pharmacopœia Officinalis & Extemporanea: Or, a Compleat English Dispensatory, publ. A Bell (2nd ed., very much Improv'd), page 437.

Which exulceration of mind made him apt to take all occaſions of contradiction.

1594, Richard Hooker, The Second Booke of Ecclesiasticall Politie