Definition of "overdistention"

We acknowledge that the tidal volume utilized for the SHVT group is far from the one utilized in the clinical setting, however, this choice was based on our previous studies supporting that 20 ml/kg was the minimal level of overdistention in healthy rats causing an identifiable injury comparable to that experienced by ALI patients.

2015 July 6, “Lung Transcriptomics during Protective Ventilatory Support in Sepsis-Induced Acute Lung Injury”, in PLOS ONE‎