Definition of "refractory"

[…] in most instances attempts to coerce the refractory and disobedient have been the signals of bloody wars, […]

1787, Alexander Hamilton, “No. 16”, in The Federalist, published 1863, page 103

Mr. Weller knocked at the door, and after a pretty long interval—occupied by the party without, in whistling a tune, and by the party within, in persuading a refractory flat candle to allow itself to be lighted […]

1836 March – 1837 October, Charles Dickens, “Chapter 26”, in The Posthumous Papers of the Pickwick Club, London: Chapman and Hall, […], published 1837

For five minutes Pollyanna worked swiftly, deftly, combing a refractory curl into fluffiness, perking up a drooping ruffle at the neck, or shaking a pillow into plumpness so that the head might have a better pose. Meanwhile the sick woman, frowning prodigiously, and openly scoffing at the whole procedure, was, in spite of herself, beginning to tingle with a feeling perilously near to excitement.

1913, Eleanor H. Porter, chapter 8, in Pollyanna‎, L.C. Page

Pure lime is extremely refractory, but readily fusible if any silex is brought in contact with it; […]

1855, Frederick Overman, A Treatise on Metallurgy‎, page 315

Many of the vague and refractory cases of neck and shoulder pain and of migraine may be due to cervical disc disease.

1949, Albert Fields, John Hoesley, “Neck and Shoulder Pain”, in Calif. Med., 70(6):478-482

In 33 adult patients with long standing refractory epilepsy on treatment with one or two standard anti-convulsant drugs,

1990, H. A. Ring et al., “Vigabatrin: rational treatment for chronic epilepsy”, in J. Neurol. Neurosurg.Psychiatry, 53(12):1051-1055

The production of a generator potential leaves a refractory state in the receptor membrane […]

1959, Nobusada Ishiko, Werner R. Loewenstein, “Electrical output of a receptor membrane”, in Science, 130:1405-6

The […] delivery of external stimuli […] delineates the pacemaker refractory period after the emission of a pacing stimulus and after the sensing of a spontaneous beat.

1970, S.S. Barold et al., “Chest wall stimulation in evaluation of patients with implanted ventricular-inhibited demand pacemakers”, in Br. Heart J., 32(6):783-789