Definition of "unsex"

Lady Macbeth: Come, you spiritsThat tend on mortal thoughts! unsex me here,And fill me from the crown to the toe fullOf direst cruelty:

c. 1606 (date written), William Shakespeare, “The Tragedie of Macbeth”, in Mr. William Shakespeares Comedies, Histories, & Tragedies […] (First Folio), London: […] Isaac Iaggard, and Ed[ward] Blount, published 1623, [Act I, scene v]

The Amazon cut off a breat to battle: How will not Woman disfigure and unsex herself to gain her end?

1859, George Meredith, chapter 1, in The Ordeal of Richard Feverel. A History of Father and Son. […], volumes (please specify |volume=I to III), London: Chapman and Hall

The Sea-king, Ravisher of IliumKnows not her false and slavering tongue, thrust out,Lewd bitch, to lick and fawn and smile and beThe secret soul of unforgiving hell!Dare it, She-devil! Unsex thyself, and be His murderess!

c. 1920–1925 , Geoffrey Montague Cookson, transl., Agamemnon, translation of original by Aeschylus

[…] she had expected the worst ever since Drusilla had deliberately tried to unsex herself by refusing to feel any natural grief at the death in battle not only of her affianced husband but of her own father […]

1935 April, William Faulkner, “Skirmish at Sartoris”, in The Unvanquished, New York, N.Y.: Random House, published 1938; republished in The Unvanquished: The Corrected Text, New York, N.Y.: Vintage Books, October 1991, section 1, page 189