Definition of "vertuous"

TO THE GODLY AND VERTUOUS LADY, THE LADY JANE DEUOREUX, OF MERIUALE.

1591, Michael Drayton, The Harmonie of the Church

Doſt thou thinke becauſe thou art vertuous, there ſhall be no more Cakes and Ale?

c. 1601–1602 (date written), William Shakespeare, “Twelfe Night, or What You Will”, in Mr. William Shakespeares Comedies, Histories, & Tragedies […] (First Folio), London: […] Isaac Iaggard, and Ed[ward] Blount, published 1623, [Act II, scene iii], page 261

To my Vertuous, No less than in all things else Deserving NIECE, Mrs. ELIZABETH DRAPER.

1659, Francis Osborne, A Miscellany of Sundry Essays