Definition of "vicissitude" (often in the plural) A change , especially in one 's life or fortunes . quotations examples
Quotations And God made .. the Stars , and set them in the firmament of Heaven to illuminate the Earth , and rule the day in their vicissitude ...
1667, John Milton, “Book VII”, in Paradise Lost. […], London: […] [Samuel Simmons], […]; republished as Paradise Lost in Ten Books: […], London: Basil Montagu Pickering […], 1873,
Despite all the monarchy ’s vicissitudes , however , Queen Elizabeth II , a figure from another age , who was stiff and formal and not noticeably particularly warm and empathetic , had won and retained the affection , loyalty and support of the overwhelming majority of the British public , who respected her for her diligence and sense of duty .
September 8 2022, Stephen Bates, “Queen Elizabeth II obituary”, in The Guardian