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A region in Southwest Asia spanning from the rivers Euphrates and Tigris that is the site of one of the most ancient civilizations in the history of man. quotations examples
It was purchased by the Isle of Wight Railway in 1882, and continued to work between Brading and Bembridge until 1917, when it was taken over by the War Department, and sent overseas for war service in Mesopotamia, whence it never returned. It survived until at least 1921, when it was observed on the quayside at Basra.
1948 July and August, K. Westcott Jones, “The Isle of Wight Railway”, in Railway Magazine, page 217
(historical) The British Mandate of Mesopotamia, a League of Nations mandate from 1920 to 1932 that was the precursor to the independent state of Iraq.
(UK, slang, obsolete) The Eaton Square district of London, England.