Definition of "derangement"

His [James Stewart's] postwar roles, full of myopic obsession, stalkerish derangement, and a desire for vengeance, don't seem like ground Hanks is willing to cover.

2021 February 9, Christina Newland, “Is Tom Hanks part of a dying breed of genuine movie stars?”, in BBC‎

Young as he was at the time, he had seen the imprudence of Mr. Granard's way of living; he had often remonstrated, and the death of his father, with the subsequent derangement of his affairs, had alone prevented his following up his advice with such assistance as would have made it effectual.

1838 (date written), L[etitia] E[lizabeth] L[andon], chapter VII, in Lady Anne Granard; or, Keeping up Appearances. […], volume I, London: Henry Colburn, […], published 1842, page 93

8-1. On 21 April 1943, while operating off the Malay Peninsula during her sixth war patrol, GRENADIER sustained heavy damage to the after portion of the ship as the result of a Japanese aircraft depth bomb attack. The most serious casualty which occurred, and which directly caused GRENADIER'S loss, was the complete immobilization of her propulsion plant due to derangement of the main control cubicle and severe misalignment of the propeller shafting. All efforts by ship's force to effect emergency repairs were unsuccessful. Early the next morning, GRENADIER was abandoned and scuttled by her own crew to prevent imminent capture by an approaching Japanese merchant ship.

1949 January 1, Bureau of Ships, “U.S.S. GRENADIER (SS210), Loss in Action, Off Malaya, 22 April 1943”, in Submarine Report: Depth Charge, Bomb, Mine, Torpedo and Gunfire Damage, Including Losses in Action, 7 December 1941 to 15 August 1945‎, volume 1, United States Hydrographic Office, archived from the original on 9 December 2022, page 83