Definition of "tweak"
tweak
/twiːk/
verb
third-person singular simple present tweaks, present participle tweaking, simple past and past participle tweaked
(intransitive, US, slang) To abuse methamphetamines, especially crystal meth.
(intransitive, US, slang) To exhibit extreme nervousness, evasiveness when confronted by authorities, compulsiveness, erratic motion, excitability, etc, due to or mimicking the symptoms of methamphetamine abuse.